Accelerating the discovery and clinical testing of anti-aging drugs.

Hear from the authors of a Frontiers in Science lead article as they set out a roadmap for translating “aging rate indicators” (ARIs) from mouse studies into human clinical research—and how these indicators could make healthy aging research faster, less expensive, and more practical.

The article examines why anti-aging drug research is hampered by the lack of a practical way to measure the rate of aging itself. The authors outline 12 candidate ARIs—physiological and molecular changes associated with a slow-aging state across multiple mouse models and interventions—that could help identify whether a diet or drug is shifting the body toward a slow-aging state, without needing to wait for lifespan studies to run their course.

Join the authors and an expert panel to discuss the biology of aging rate and the future of ARI research. This includes the need for replication across laboratories and mouse stocks, the development of plasma-based indicators that could eventually be measured in humans, and how these findings might extend beyond mice to dogs, non-human primates, and eventually clinical trials in people.