

Frontiers Forum Deep Dive series
NANOSPRESSO: toward personalized locally produced nucleic acid nanomedicines
9 July 2025 | 16:00-17:30 CEST
A new point-of-care model for affordable, on-demand production of personalized nucleic acid nanomedicines could revolutionize how hospitals treat rare diseases.

Speakers
-
Prof Raymond Schiffelers
University Medical Center Utrecht, the Netherlands
-
Prof Sabine Fuchs
University Medical Center Utrecht, the Netherlands
-
Dr Alexandre Ceccaldi
European Technology Platform on Nanomedicine (ETPN), France
-
Olivia Lewis
Utrecht University, the Netherlands
-
Alexandra Heumber Perry
Rare Diseases International, Switzerland

A new frontier in rare disease treatment
The NANOSPRESSO platform, published in a Frontiers in Science lead article, could enable hospital pharmacists to rapidly create inexpensive, personalized therapeutic cartridges—akin to espresso capsules—for rare disease patients at their bedside.
Join the article authors for an in-depth discussion on how NANOSPRESSO could boost access to personalized nucleic acid therapies, even in low-resource settings, and overcome regulatory challenges.
Hear our expert panel explore how NANOSPRESSO could open up treatments for underfunded and underserved rare conditions worldwide—which affect 36 million patients in the EU alone.
Agenda
Why rare diseases demand a new model: the case for decentralizing personalized treatment production
Overcoming pharmaceutical and regulatory barriers for nucleic acid therapeutics
Ensuring quality, affordability, and equity in local production: practical, regulatory, and ethical considerations.
RNA and LNP-based therapeutics: from pandemic response to personalized rare disease care
NANOSPRESSO: a scalable platform for bedside manufacturing of nucleic acid nanomedicines
Charting a path forward | Panel discussion and Q&A
Speaker and contributor bios
-
Raymond Schiffelers
Professor of Nanomedicine, CDL Research, University Medical Center Utrecht, the Netherlands
Prof Raymond Schiffelers is a leading expert in nanomedicine and targeted drug delivery. His pioneering research focuses on the development of nanoparticle-based systems for precision drug transport, with particular emphasis on targeting tumor vasculature, developing polymers for siRNA delivery, and utilizing extracellular vesicles as novel templates for drug delivery and diagnostics.
A key figure in several European consortia, he is also a founding member of the International Society for Extracellular Vesicles (ISEV) and the immediate past chair of the European Technology Platform on Nanomedicine. Raymond serves as Associate Editor of the Journal of Extracellular Vesicles and is an editor for both the International Journal of Pharmaceutics and the Journal of Controlled Release.
He continues to shape policy and regulatory frameworks to accelerate the safe and effective integration of nanotechnologies into modern healthcare. Recently, Raymond received the prestigious Advanced Grant from the European Research Council (ERC) for his research on smart nanoparticles for cancer therapy.
-
Sabine Fuchs
Associate Professor and Pediatrician, University Medical Center Utrecht, the Netherlands
Prof Sabine Fuchs is an associate professor and pediatrician specializing in metabolic diseases at the University Medical Center Utrecht and Principal Investigator at Regenerative Medicine Center Utrecht (RMCU) at the Hubrecht Institute.
Sabine earned doctoral and postdoctoral degrees in both pharmacy and medicine, completing her internship at Harvard Medical School. Combining her pediatric training with a PhD in metabolic diseases, she now leads a multidisciplinary team focused on the diagnosis and treatment of rare genetic and metabolic diseases, including pioneering liver organoid technologies, functional genomics, and biobanking.
Sabine has received prestigious awards, including the ERC Starting Grant and the Elisabeth von Freyburg Penning. She is dedicated to advancing patient care and mentoring clinician-scientists through her leadership in education and talent programs such as TULIPS (Training Upcoming Leaders in Pediatric Science) and the EUREKA Certificate Program for Translational Medicine.
-
Alexandre Ceccaldi
General Secretary, European Technology Platform on Nanomedicine (ETPN), France
Dr Alexandre Ceccaldi leads the European Technology Platform on Nanomedicine (ETPN), the driving force behind Europe’s nanomedicine agenda—a network of over 130 academic, industrial and healthcare organizations. He is also coordinator of the NOBEL European Project—spanning diagnostics, targeted drug delivery, regenerative medicine, and digital health convergence.
Alexandre earned a PhD in Biology from Université Pierre et Marie Curie and a degree in engineering from AgroParisTech, grounding his career in cutting‑edge cancer research and stem‑cell therapeutics. Previously, he managed INGESTEM, France’s first national public consortium dedicated to induced pluripotent stem cells and their medical applications.
Alexandre’s passion for innovation in healthcare is driven by the desire to change the life of millions of patients every year. He is committed to uniting Europe’s nanomedicine community to accelerate clinical translation: driving collaborative frameworks and propelling innovative technologies that improve patient outcomes on a continental scale.
-
Olivia Lewis
PhD student, Utrecht University, the Netherlands
Olivia Lewis (MSc) is a PhD student specializing in drug regulatory science at Utrecht University. As part of the NANOSPRESSO-NL project, Olivia’s role and the focus of her doctoral research is to investigate regulatory pathways and challenges related to the localized preparation of high-quality, personalized nucleic acid nanomedicines.
With two Master's degrees, one in molecular bioscience and one in global health, Olivia is motivated by complex transdisciplinary issues that bridge scientific innovation and society, aiming to enhance public health through smarter, more responsive drug regulation. She is committed to supporting the development of innovative understandings, perspectives, and solutions to these complex challenges.
-
Alexandra Heumber Perry
Alexandra Heumber Perry, CEO, Rare Diseases International, Switzerland
Alexandra Heumber Perry is an accomplished global health leader who has dedicated her entire career to improving healthcare policies for people living with diseases, with a particular focus on neglected and vulnerable populations.
With over two decades of international experience in policy, patient advocacy, and public affairs, Alexandra has advised major organizations such as The Lancet Commission and the World Obesity Federation. She established the International Alliance for Myalgic Encephalomyelitis, significantly raising the disease’s profile at the World Health Organization (WHO) and among policymakers. She served as Head of Policy Affairs at the Drugs for Neglected Diseases initiative (DNDi), achieving impactful policy shifts for neglected diseases, and held earlier roles with Médecins Sans Frontières and Health Canada.
In her current role as CEO of Rare Diseases International, Alexandra drives global strategies to raise awareness of rare diseases, improve access to diagnostics, treatments and care, advocate for the rights of patients worldwide, to improve the lives of people living with rare diseases.